Purity >98%. (±)8(9)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid . (±)8(9)-EET is a major cytochrome P450 (CYP450) metabolite in the renal cortex. It activates PPARAlpha in HEK293 cells when used at a concentration of 1 μM but inhibits NF-KappaB activity induced by IL-1Beta in a PPARAlpha-dependent and -independent fashion. It is also a substrate of COX-1 and COX-2, as measured by oxygen consumption and product formation assays when used at a concentration of 50 μM. (8S,9R)-EET (1 μg/kg), but not (8R,9S)-EET, reduces the glomerular filtration rate (GFR) through COX-dependent pre-glomerular vasoconstriction in rats.