A selective COX-2 inhibitor (IC50s = 22.9 and 0.05 μM for COX-1 and COX-2, respectively); reduces production of IL-1β, TNF-α, and MMP-3 as well as articular cartilage damage in a rabbit model of osteoarthritis at 3 ml of a 0.4% solution; reduces blood glucose and improves renal function and memory deficits in rats with streptozotocin-induced diabetes; displays chemopreventive activity in multiple tumor types via proapoptotic effects that are independent of COX-2 inhibition