Aldehyde Dehydrogenase 2 Family (Mitochondrial) (ALDH2)
Clone
8D4-D6-D11
Host Species
Mouse
Reactive Species
human
Isotype
IgG1
Format
affinity purified
Size
100 μL
Concentration
n/a
Applications
Western Blotting (WB)
Reviews / Ratings
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Description
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase,cytosolic and mitochondrial,can be distinguished by their electrophoretic mobilities,kinetic properties,and subcellular localizations. Most Caucasians have two major isozymes,while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform,which has a low Km for acetaldehydes,and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq,Mar 2011]Subunit structure: Homotetramer. Subcellular location: Mitochondrion matrix. Sequence similarities: Belongs to the aldehyde dehydrogenase family.
Immunogen
Purified recombinant human ALDH2 protein fragments expressed in E.coli