A site-1 protease inhibitor (IC50 =170 nM against human recombinant site-1 protease); selective for site-1 protease over trypsin, elastase, proteinase K, plasmin, kallikren, factor XIa, thrombin, and furin at concentrations up to 100 μM; inhibits proteolytic processing and nuclear translocation of SREBP; reduces expression of HMG-CoA synthase and fatty acid synthase (EC50s = 0.3 and 2 μM, respectively) and inhibits cholesterol synthesis (EC50 = 600 nM) in HepG2 cells; reduces cholesterol and fatty acid synthesis in CD-1 mice; inhibits replication of dengue virus serotypes 1-4 in infected HeLa cells; reduces growth of T98G, U87-MG, and A172 glioblastoma cells (IC50s = 0.32, 15.2, and 27.6 μM, respectively),