Recombinant Human Holliday junction recognition protein (HJURP)
Description
Purity > 90% as determined by SDS-PAGE. MW: 99.5kDa. Full Length: 1-748aa. N-terminal 6xHis-SUMO-tagged. Homo sapiens (Human). Centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. Acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. Prevents CENPA-H4 tetramerization and prevents prature DNA binding by the CENPA-H4 tetramer. Directly binds Holliday junctions.
Size
100ug
Concentration
n/a
Applications
RUO
Other Names
14-3-3-associated AKT substrateFetal liver-expressing gene 1 proteinUp-regulated in lung cancer 9