A nitrone free radical spin trap with neuroprotective properties; inhibits transport of tPA from the luminal to the abluminal compartment in an in vitro BBB model under ischemic conditions at 250 μM; decreases infarct volume by 59% in a rat model of transient ischemia induced by MCA occlusion at 10 mg/kg per hour; decreases functional disability in the hemiparetic arm of marmosets in the Hill-and-Valley staircase, two-tube choice, and six-tube search tests following MCA occlusion-induced ischemia at 16 mg/kg per hour