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Description
Alexa Fluor? 488 anti-Myelin Basic Protein. Myelin basic protein (MBP) is a protein involved in the myelination of nerves in the central nervous system (CNS). MBP functions to maintain the correct structure of myelin, through its interaction with the lipids in the myelin membrane. The myelin sheath is made up of MBP and lipids, and acts as an insulator to increase the velocity of axonal impulse conduction. MBP plays a central role in the demyelinating disease multiple sclerosis (MS). A hallmark of the disease is the loss of the myelin sheath surrounding nerves, thought to be induced by antibodies against MBP.
Immunogen
Recombinant MBP protein fragment corresponding to amino acid residues 1-197
Other Names
MBP, Golli-MBP, myelin A1 protein, myelin membrane encephalitogenic protein