An uncharged, 1,4-di-substituted, phenyl-linked bis-TFMS phosphate mimetic that acts as a reversible, competitive, and active-site directed inhibitor of SHP-2, PTP1B, PTP-ε, PTP-Meg-2, PTP-σ, PTP-β, and PTP-μ (IC50s = 1.8, 2.5, 8.4, 13, 20, 6.4, and 6.7 μM, respectively)