Immunohistochemistry: 1:200-1:2000, Western Blot: 1:200-1:2000
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Description
MAP1LC3C Polyclonal Antibody. Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. Probably involved in formation of autophagosomal vacuoles (autophagosomes). 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. Most abundant in placenta, lung and ovary. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosoli